2002 * BIBLIOGRAPHY

Li, L., Sharipo, A., Chaves-Olarte, E., Masucci, M.G., Levitsky,V., Thelestam, M., Frisan,T.,2002. 

The Haemophilus ducreyi cytolethal distending toxin recruits the Mre11 repair complex in proliferating and non-proliferating cells. Cellular Microbiol. 4, 87-99.

Saravia, P. et al. 2002. 

Geographic and ontogenic variability in the venom of the neotropical rattlesnake Crotalus durissus: Pathophysiological and therapeutic implications. Rev. Biol. Trop. 50(1)

Watanabe, L., Rucavado, A., Kamiguti, A., Theakston, R.D.G., Gutiérrez, J.M. 6 Arni, R.K. (2002)

Crystallization and preliminary diffraction data of BaP1, a haemorrhagic metalloproteinase from Bothrops asper snake venom.  Acta Crystallographica D58: 1034-1035.

2001 * BIBLIOGRAPHY

Cortes-Bratti, X., Karlsson, C., Lagergård, T., Thelestam, M. and Frisan, T. 2001. 

The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways. J. Biol. Chem. 276, 5296-5302.

Cortes-Bratti,X., Frisan,T. and Thelestam,M. 2001.

The cytolethal distending toxins induce DNA damage and cell cycle arrest. Toxicon, 39, 1729-1736. 

Díaz, C., León, G., Rucavado, A., Rojas, N., Schroit, A.J.& Gutiérrez, J.M. (2001)

Modulation of the susceptibility of human erythrocytes to snake venom myotoxic phospholipases A₂: role of negatively charged phospholipids as potential membrane binding sites.  Arch. Biochem. Biophys. 391: 56-64.

León, G., Monge, M., Rojas, E., Lomonte, B. & Gutiérrez, J.M. (2001)

Comparison between IgG and F(ab’)₂ polyvalent antivenoms: neutralization of systemic effects induced by Bothrops asper venom in mice, extravasation to muscle tissue, and potential of adverse reactions.  Toxicon 39: 793-801. 

Lopes-Ferreira, M., Núñez, J., Rucavado, A., Farsky, S.H., Lomonte, B., Angulo, Y., Moura da Silva, A.M. & Gutiérrez, J.M. (2001)

Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice. Int. J. Exp. Pathol. 82: 55-64.

Rojas, E., Saravia, P., Angulo, Y., Arce, V., Lomonte, B., Chávez, J.J., Velásquez, R., Thelestam, M. & Gutiérrez, J.M. (2001)

Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A₂ homologue and neutralization by two antivenoms.  Comp. Biochem. Physiol. 129: 51-162.

Rucavado, A., Soto, M., Kammiguti, A.S., Theakston, R.D.G., Fox, J.W., Escalante, T. & Gutiérrez, J.M. (2001)

Characterization of aspercetin, a platelet aggregating component from the venom of the snake Bothrops asper which induces thrombocytopenia and potentiates metalloproteinase-induced hemorrhage.  Thrombosis and Haemostasis 85: 710-715.

Saravia, P., Rojas, E., Escalante, T., Arce, V., Chaves, E., Velasquez, R., Lomonte, B., Rojas, G., and Gutierrez, JM., 2001.

The venom of Bothrops asper from Guatemala: toxic activities and neutralization by antivenoms. Toxicon. 39(2-3):401-405, Feb-Mar.

Zamunér, S.R., Gutiérrez, J.M., Muscará, M.N., Teixeira, S.A. & Teixeira, C.F.P. (2001)

Bothrops asper and Bothrops jararaca snake venoms trigger microbicidal functions of peritoneal leukocytes in vivo.  Toxicon 39: 1505-1513.

1999 * BIBLIOGRAPHY

Alape-Girón A., Persson, B., Cedelund, E., Flores-Díaz, M., Gutiérrez, J.M., Thelestam, M., Bergman, T., & Jörnvall, H. (1999).

Elapid venom toxins: multiple recruitment of ancient scaffolds. European Journal of Biochemistry 259, 225-234.

Arni, R.K., Fontes, M.R.M., Barberato, C., Gutiérrez, J.M., Díaz, C. & Ward, R.J. (1999)

Crystal structure of myotoxin II, a monomeric Lys49-phospholipase A2 homologue isolated from the venom of Cerrophidion (Bothrops) godmani.  Arch. Biochem. Biophys. 366, 177-182.

Chaves-Olarte,E., Löw,P., Freer,E., Norlin,T., Weidmann, M., Eichel-Streiber,Cv. and Thelestam,M. 1999. 

A novel cytotoxin from Clostridium difficile serogroup F is a functional hybrid between two other large clostridial cytotoxins. J. Biol. Chem. 274, 11046-11052.

Cortes-Bratti,X., Chaves-Olarte,E., Lagergård,T. and Thelestam,M. 1999. 

A cytotoxin from the chancroid bacterium Haemophilus ducreyi induces cell cycle arrest in the G2 phase. J. Clin. Invest 103, 107-115.

de Azevedo Jr, W.F., Ward, R.J., Gutiérrez, J.M. & Arni, R.K. (1999)

Structure of a Lys49-phospholipase A2 homologue isolated from the venom of Bothrops nummifer (jumping viper).  Toxicon 37, 371-384.

Gutiérrez, J.M., Rucavado, A. & Ovadia, M. (1999)

Metalloproteinase inhibitors in snakebirte envenomations.  Drug Discovery Today 4, 532-533.

León, G., Stiles B., Alape, A., Rojas, G. & Gutiérrez, J.M. (1999)

Comparative study on the ability of IgG and F(ab')2 antivenoms to neutralize lethal and myotoxic effects induced by Micrurus nigrocinctus (Coral snake) venom. Am. J. Trop. Med. Hyg. 61, 266-271.

Lomonte, B., Angulo, Y., Rufini, S., Cho, W., Giglio, J.R., Ohno, M., Daniele, J.J., Geoghegan, P. & Gutiérrez, J.M. (1999)

Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro. Toxicon 37, 145-158.

Lomonte, B., J. Pizarro-Cerda, Y. Angulo, J. P. Gorvel, and E. Moreno. 1999.

Expression of myotoxicity and enhanced membrane-damaging activity by TyrÙTrp-substituted peptide 115-129 of myotoxin II, a Lys49 phospholipase A2 from Bothrops asper snake venom. Biochem. Byophys. Acata. 1461:19-26. 

Otero, R., Gutiérrez, J.M., Rojas, G., Núñez, V., Díaz, A., Miranda, E., Uribe, A.F., Silva, J.F., Ospina, J.G., Medina, Y., Toro, M.F., García, M.E., León, G., García, M., Lizano, S. & the regional groups in antivenom therapy research (REGATHER) (1999)

A randomized blinded clinical trial of two antivenoms, prepared by caprylic acid or ammonium sulphate fractionation of IgG, in Bothrops and Porthidium snake bites in Colombia. Correlation between safety and biochemical characteristics of antivenoms.  Toxicon 37: 895-908.

Rucavado, A., Flores-Sánchez, E., Franceschi, A., Magalhaes, A. & Gutiérrez, J.M. (1999)

Characterization of local tissue damage induced by LHF-II, a metalloproteinase with weak hemorhagic activity isolated from Lachesis muta muta venom.  Toxicon 37, 1297-1312.

Thelestam,M., Chaves-Olarte, E., Moos,M. and Eichel-Streiber,Cv. 1999. 

Clostridial toxins acting on the cytoskeleton. Chapter 8 in The Comprehensive Sourcebook of Bacterial Protein Toxins (Eds. J.E. Alouf and J.Freer), Academic Press, London., pp. 147-173. 

1998 * BIBLIOGRAPHY

Chaves-Olarte,E., Cortes-Bratti,X. and Thelestam,M., 1998. 

Effects of bacterial toxins on small GTP-binding proteins. Toxicology In Vitro, 12, 527-531.

Chaves-Olarte,E., Weidmann,M., Eichel-Streiber,Cv., and Thelestam,M. 1998. 

Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities and surface binding to cultured cells. In: Bacterial Protein Toxins (Eds. J. Hacker et al), Gustav Fischer Verlag, Stuttgart, pp. 74-75

de Sousa, M.V., Morhy, L., Arni, R.K., Ward, R.J., Díaz, C., & Gutiérrez, J.M. (1998)

Amino acid sequence of a myotoxic Lys49-phospholipase A2 homologue from the venom of Cerrophidion (Bothrops) godmani. Biochimica et Biophysica Acta 1384, 204-208.

Flores-Diaz,M., Alape-Girón,A., Titball,R.W., Moos,M., Guillouard,I., Cole,S., Howells,A.M., Eichel-Streiber,Cv., Florin, I. and Thelestam, M. 1998. 

UDP-glucose deficiency causes hypersensitivity to the cytotoxic effect of Clostridium perfringens phospholipase C. J. Biol. Chem. 273, 24433-24438.

Gutiérrez, J.M. & Ovadia, M. (1998)

Bothrops asper hemorrhagic proteinases BaH1 and BaP1. In:  Handbook of Proteolytic Enzymes, pp 1295-1297 (Barrett, A.L., Rawlings, N.D., and Woessner,  J.F., Eds.). London, Academic Press.

Gutiérrez, J.M., León, G., Rojas, G., Lomonte, B., Rucavado, A. & Chaves, F. (1998)

Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom.  Toxicon 36, 1529-1538.

León, G., Estrada, R., Chaves, F., Rojas, G. & Gutiérrez, J.M. (1998)

Inhibition by CaNa2-EDTA of local tissue damage induced by B. asper (terciopelo) venom: application in horse immunization for antivenom production. Toxicon 36, 321-331.

Rucavado, A., Núñez, J. & Gutiérrez, J.M. (1998)

Blister formation and skin damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper.  International Journal of Experimental Pathology 79, 245-254. 

Thelestam,M., Flores-Díaz,M., Alape-Girón,A., Titball,R., Pollesello,P., Persson,B., Moos,M., Chaves-Olarte,E., Lofrumento,D., Cortes-Bratti,X., Bergman,T., Eichel-Streiber,Cv., and Florin,I. 1998. 

A UDP-glucose deficient cell mutant as a model to study the molecular mechanism of cytotoxicity induced by Clostridium perfringens phospholipase C in ischemic tissue. In: Bacterial Protein Toxins (Eds. J. Hacker et al), Gustav Fischer Verlag, Stuttgart, pp. 184-191.

1997 * BIBLIOGRAPHY

Alape-Girón, A., Miranda-Arrieta, K., Cortés-Bratti, X., Stiles, B.G. & Gutiérrez, J.M. (1997)

A comparison of in vitro methods for assessing the potency of therapeutic antisera against the venom of the coral snake Micrurus nigrocinctus. Toxicon 35, 573-581.

Amuy, E., Alape-Giron, A., Lomonte, B., Thelestam, M. & Gutiérrez, J.M. (1997)

Development of immunoassays for determination of circulating venom antigens during coral snakes (Micrurus sp.) envenomations. Toxicon 35, 1605-1616.

Angulo, Y., Chaves, E., Alape, A., Rucavado, A., Gutierrez, J. M., and Lomonte, B. 1997.

Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica. Archives of Biochemistry and Biophysics, 339:260-266.

Angulo, Y., Estrada, R. & Gutiérrez, J.M. (1997)

Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom. Toxicon 35, 81-90.

Chaves-Olarte, E., Weidmann, M., Eichel-Streiber, Cv. and Thelestam, M. 

1997. Toxins A and B from Clostridium difficile differ with respect to enzymatic potencies, cellular substrate specificities and surface binding to cultured cells. J. Clin. Invest. 100, 1734-1741

Díaz, C. & Gutiérrez, J.M. (1997)

Chemical modification of histidine and lysine residues of myotoxic phospholipases A2 isolated from Bothrops asper and Bothrops godmani snake venoms: effects on enzymatic and pharmacological properties. Toxicon 35, 241-252.

Flores-Díaz M., Alape-Girón,A., Persson,B., Pollesello,P., Moos,M., Eichel-Streiber,Cv., Thelestam,M., and Florin,I. 

1997. Cellular UDP-glucose deficiency caused by a single point mutation in the UDP-glucose pyrophosphorylase gene. J. Biol. Chem. 272, 23784-23791.

León, G., Rojas, G., Lomonte, B. & Gutiérrez, J.M. (1997)

Immunoglobulin G and F(ab')2 Polyvalent antivenoms do not differ in their ability to  neutralize hemorrhage, edema and myonecrosis induced by Bothrops asper (terciopelo) snake venom. Toxicon, 35, 1627-1637.

Lizano, S., Lomonte, B., Fox, J.W. and Gutiérrez, J.M. (1997)

Biochemical characterization and pharmacological properties of a phospholipase A2 myotoxin inhibitor from the plasma of the snake Bothrops asper. Biochemical Journal 326, 853-859.

Thelestam,M., Florin,I. & Chaves-Olarte,E. 1997. 

Review: Clostridium difficile toxins. Chapter 12 in: Bacterial Toxins – Tools in Cell Biology and Pharmacology (Ed. K. Aktories), pp. 141-158

1995 * BIBLIOGRAPHY

Arni, R.K., Ward, R.J., Gutiérrez, J.M. & Tulinsky, A. (1995)

Crystal structure of a calcium-independent phospholipase-like myotoxic protein from Bothrops asper venom. Acta Crystallographica D51, 311-317.

Bogarín, G., Segura, E., Durán, G., Lomonte, B., Rojas, G. & Gutiérrez, J.M. (1995)

Evaluación de la capacidad de cuatro antivenenos comerciales para neutralizar el veneno de la serpiente Bothrops asper (terciopelo) de Costa Rica. Toxicon 33, 1242-1247.

Borkow, G., Gutiérrez, J.M. & Ovadia, M. (1995)

Isolation, characterization and mode of neutralization of a potent antihemorrhagic factor from the serum of the snake Bothrops asper. Biochimica et Biophysica Acta 1245, 232-238.

Díaz, C., Lomonte, B., Zamudio, F. & Gutiérrez, J.M. (1995)

Purification and characterization of myotoxin IV, a phospholipase A2 variant, from Bothrops asper snake venom. Natural Toxins 3, 26-31.

Gutiérrez, J.M. & Lomonte, B. (1995)

Phospholipase A2 myotoxins from Bothrops snake venoms. Toxicon 33, 1405-1424.

Gutiérrez, J.M., Romero, M., Díaz, C., Borkow, G. & Ovadia, M. (1995)

Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo). Toxicon 33, 19-29.

Gutiérrez, J.M., Romero, M., Núñez, J., Chaves, F., Borkow, G. & Ovadia, M. (1995)

Skeletal muscle necrosis and regeneration after injection of BaH1, a hemorrhagic metalloproteinase isolated from the venom of the snake Bothrops asper (terciopelo). Experimental and Molecular Pathology 62, 28-41.

Otero, R., Núñez, V., Osorio, R.G., Gutiérrez, J.M., Giraldo, C.A. & Posada, L.E. (1995)

Ability of six Latin American antivenoms to neutralize the venom of mapaná equis (Bothrops atrox) from Antioquia and Chocó (Colombia). Toxicon 33, 809-815.

Pedersen, J.Z., Lomonte, B., Massoud, R., Gubensek, F., Gutiérrez, J.M. & Rufini, S. (1995)

Autocatalytic acylation of phospholipase-like myotoxins. Biochemistry 34, 4670-4675.

Rucavado, A., Borkow, G., Ovadia, M. & Gutiérrez, J.M. (1995)

Immunological studies on BaH1 and BaP1, two hemorrhagic metalloproteinases from the venom of the snake Bothrops asper. Toxicon 33, 1103-1106

Rucavado, A., Lomonte, B., Ovadia, M. & Gutiérrez, J.M. (1995)

Local tissue damage induced by BaP1, a metalloproteinase isolated from Bothrops asper (Terciopelo) snake venom. Experimental and Molecular Pathology 63, 186-199.